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Content 7



Naltrexone, Low-Dose Naltrexone (LDN) | Research Trials Reference | Helpful Reference Links

What is Naltrexone and how does it work?

  • Naltrexone 50mg is a medication, approved in the 1980’s, for treatment of opium and heroin addiction. Today, Naltrexone is also indicated for alcohol dependence.
  • Drugs such as heroin bind to opioid receptors. Naltrexone takes the place of heroin on the opioid receptor, inhibiting the effect of heroin on the body (i.e. naltrexone is an opioid antagonist).

What is Low-Dose Naltrexone (LDN) and
how does it work?

  • Opioid receptors are present in every body tissue and every cell in the body’s immune system.
  • Drugs are not the only ones that can bind to these opioid receptors. The brain and adrenal glands produce opioid hormones called beta-endorphins and enkephalins. These opioid hormones can bind to opioid receptors as well.
  • A deficiency in opioid hormones (i.e. endorphins) can trigger cancers and autoimmune disorders, as these hormones serve as immunomodulators.
  • Naltrexone, when taken in a very low dose every night at bedtime, provides a brief blockade of opioid receptors between 2 A.M. and 4 A.M. This blockade leads to an increase in the secretion of endogenous endorphins, increase in the number of receptors, and increase in the sensitivity of receptors, which ultimately halts disease progression, as it enhances the immune system, initiating a stronger natural body response.
  • Clinical practice has proven the efficacy of LDN. Dr. Bernard Bihari, a New York City physician, had seen the effects of low-dose naltrexone in his clinical practice. In 1985, he determined that low dose naltrexone every night at bedtime improved patients physiological response to HIV. In the mid 1990’s, he found that patients with cancer could also benefit drastically from this treatment, along with patients with patients who have autoimmune diseases such as lupus.
  • Research has also proven the efficacy of LDN. Dr. Jill Smith, professor of gastroenterology at Pennsylvania State University College of Medicine, published an article in January of 2007, in the American Journal of Gastroenterology, concluding that “LDN therapy appears effective and safe in subjects with active Crohn’s disease.”
 LDN 2016 Information ButtonLDN effective treatment for Diseases ButtonLDN effective treatment for Diseases ButtonLDN FAQs Frequently Asked Questions ButtonLDN Auto immune disease, HIV, Cancer, MS ButtonLDN Conference Events October 5, 2013 ButtonBuy LDN at Mark Drugs compounding Pharmacy Button

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